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KMID : 0382619900100010558
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Hanyang Journal of Medicine
1990 Volume.10 No. 1 p.558 ~ p.569
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Effect of Remote Noxious Nerve Stimulation on the Dorsal Horn Cell Activity in the Cat
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Abstract
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To explore characteristics of the diffuse noxious inhibitory controls (DNIC) mechanism more in detail, the effects of remote noxious nerve stimulation (RNNS) on the background activity and evoked responses of the dorsal horn cells to mechanical and chemical stimuli were studied in the cat lumbar spinal cord.
The results obtained are summarized as follows:
1) RNNS suppressed activities of the spinal cells receiving afferent input only from the muscle, and of wide dynamic range (WDR) cells and high threshold (HT) cells receiving messages from the muscle and/or the skin. Especially the responses of dorsal horn cells to muscle input were most effectively blocked by RNNS.
2) Following RNNS also suppressed was the response of HT cells to noxious curaneous input.
3) After RNNS the responses of spinal neurons to chemical stimulus(K+ion) was suppressed in approximately two thirds (15/21 units) whereasthe response was enhanced in the rest (6/21 units).
4) The spontaneous activity of the dorsal horn cells were more effectively suppressed by afferent inputs through Aβand Aδfibers whereas the evoked activity by those through the C-fibers of radial nerves.
The results indicate that the activities of dorsal horn cells in the lumbar segment of cat spinal cord except low threshold (LT) cell can be suppressed by the diffuse noxious inhibitory control system.
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